Leslie silberstein boston

A long-term objective of Dr. To this end, the lab has developed novel quantitative imaging tools for 2D and 3D visualization of different bone marrow compartments including the distribution of both hematopoietic and non-hematopoietic cells, e.

Complemented by molecular and cellular approaches, my goal is to understand how niche cells influence the dynamic nature of hematopoiesis in health and disease. On-going studies are focused on understanding how inflammatory signals modulate niche cells and concomitantly hematopoiesis. Boston Children's Hospital Phone: Fax: leslie.

Cell Rep ; J Immunol ; J Exp Med ; Platelet refractoriness: it's not the B-all and end-all. Blood ; Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo.

Blood Transfusion Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity ; View abstract VH4. Ann N Y Acad Sci.

View abstract Immunoglobulin gene use by naturally occurring cold agglutinins. View abstract Clinical heterogeneity reflects biologic diversity in chronic lymphocytic leukemia. Crit Rev Oncol Hematol. View abstract Peripheral blood progenitor cell generation and harvesting. Semin Oncol. View abstract HIV-mediated B-lymphocyte activation and lymphomagenesis.

J Clin Immunol. View abstract Immunoglobulin gene sequence analysis to further assess B-cell origin of multiple myeloma. Clin Diagn Lab Immunol. View abstract Anti-B cell autoantibodies encoded by VH genes in human fetal spleen do not require in vivo somatic selection. Eur J Immunol. View abstract Expression and characterization of recombinant anti-Rh D antibodies on filamentous phage: a model system for isolating human red blood cell antibodies by repertoire cloning.

View abstract B-cell origin of cold agglutinins. Adv Exp Med Biol. View abstract 4-Hydroperoxycyclophosphamide purged autologous bone marrow transplantation of relapsed, responding non-Hodgkin's lymphoma with granulocyte colony stimulating factor support results in reliable hematopoietic recovery.

Prog Clin Biol Res. View abstract High-dose therapy and growth factor mobilized peripheral blood progenitor cell support for responding patients with metastatic breast cancer. View abstract Indications and guidelines for the use of hematopoietic growth factors. View abstract Current trends: evolving concepts in transfusion medicine. The need for standardization of cryoprecipitate-derived fibrin adhesive.

Transfus Sci. View abstract Differential usage of an Ig heavy chain variable region gene by human B-cell tumors. View abstract Natural and pathologic human autoimmune responses to carbohydrate antigens on red blood cells.

Springer Semin Immunopathol. Clin Immunol Immunopathol. View abstract Variable region gene analysis of an isotype-switched IgA variant of chronic lymphocytic leukemia. View abstract Leukocyte reduction in blood component therapy. Ann Intern Med. View abstract An anti-B cell autoantibody from Wiskott-Aldrich syndrome which recognizes i blood group specificity on normal human B cells. View abstract Reducing the risk for transfusion-transmitted cytomegalovirus infection.

View abstract Autologous bone marrow transplantation with in vitro chemotherapy purge in first remission of acute myeloid leukemia. View abstract Structural basis of a conserved idiotope expressed by an autoreactive human B cell lymphoma. View abstract Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens.

View abstract The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma. View abstract Variation in blood component irradiation practice: implications for prevention of transfusion-associated graft-versus-host disease.

View abstract Heterogeneity of human red cell autoantibodies assessed by isoelectric focusing. View abstract The development of selective plasmapheresis as a means for specific therapeutic intervention. View abstract Guidelines for transfusion support in patients undergoing coronary artery bypass grafting.

Ann Thorac Surg. View abstract Anti-idiotypic antibodies specific for a pathologic anti-Pr2 cold agglutinin. View abstract Prenatal and perinatal immunohematology: recommendations for serologic management of the fetus, newborn infant, and obstetric patient.

View abstract Strategies for the review of transfusion practices. View abstract Relationship of variable region genes expressed by a human B cell lymphoma secreting pathologic anti-Pr2 erythrocyte autoantibodies. View abstract Production of human warm-reacting red cell monoclonal autoantibodies by Epstein-Barr virus transformation. View abstract Production of carbohydrate-specific human monoclonal antibodies in vitro. Methods Enzymol. View abstract An autologous fibrinogen-based adhesive for use in otologic surgery.

View abstract Comparative biochemical and genetic characterization of clonally related human B-cell lines secreting pathogenic anti-Pr2 cold agglutinins. Arch Biochem Biophys. View abstract Transfusion therapy in emergency medicine. Ann Emerg Med. View abstract Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy. View abstract Efficacy of intensive plasmapheresis in thrombotic thrombocytopenic purpura.

Arch Intern Med. View abstract The efficacy of intensive plasma exchange in acquired von Willebrand's disease. View abstract Cold hemagglutinin disease associated with IgG cold-reactive antibody.

View abstract Quality control in the blood bank. Clin Lab Med. View abstract Developmental progression of myosin gene expression in cultured muscle cells. View abstract Purification to homogeneity and amino acid sequence analysis of two anionic species of human interleukin 1. View abstract Etiologic aspects of cold agglutinin disease: evidence for cytogenetically defined clones of lymphoid cells and the demonstration that an anti-Pr cold autoantibody is derived from a chromosomally aberrant B cell clone.

View abstract Thrombotic thrombocytopenic purpura with colitis in an elderly woman. View abstract Calcium homeostasis during therapeutic plasma exchange. View abstract Effect of plasma exchange on phenytoin plasma concentration.

Ther Drug Monit. Through both his leadership and research activities, he brings together Transfusion Medicine-related educational, research and clinical activities of the major Harvard Medical School affiliated institutions in Boston. Skip to main content. Main Menu Utility Menu Search. Les E. Silberstein, M. The Silberstein lab focuses on bone marrow, and aims to better define niche-induced signals and their intracellular pathways controlling stem cell development and function.

Biosketch Dr. Contact Information leslie. Websites Silberstein Lab. Les Silberstein publications.