Joachim seemann dallas

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Liszczak Lab. Lu Christopher Lab. Lu Lenette Lab. Lu Weiguo Lab. Luo Weibo Lab. Cell proliferation critically depends on the duplication organelles in interphase and the segregation between the two daughter cells during mitosis. Accurate partitioning of chromosomes and intracellular organelles is crucial to sustain cellular functions over generations. Defects in mitosis can lead to genomic instability and loss of vital organelles, which is commonly associated with the development of cancer.

While much progress has been made towards understanding the segregation of chromosomes, the mechanisms that govern the partitioning of vital organelles, in particular of the Golgi, remain largely unknown.

The mammalian Golgi is essential for secretion and post-mitotic cell survival depends on the partitioning of a functional Golgi into progeny. Our aim i s to define the underlying mechanisms that ensure the faithful partitioning of the single mammalian Golgi during mitosis. At the onset of mitosis, the highly organized Golgi structure vesiculates and reforms after equal partitioning in the two daughter cells. We previously showed that the spindle actively partitions the mammalian Golgi.

This process is initiated by the Golgi membrane protein GM, which locally activates the spindle assembly factor TPX2 to initiate microtubule polymerization. Forming microtubules are further captured and bundled by GM, thereby linking Golgi membranes to the spindle to ensure the Golgi segregation into the daughter cells.

In this proposal we plan to determine the biochemical and mechanistic basis for this process.